TRANSINO II PTP 240 tablets
Improvement of Melasma in 8 weeks.
The only melasma remedy as OTC drug as of December 2019.
TRANSINO II PTP 240 tablets

Active ingredient "tranexamic acid combination"

TRANSINO II is the only OTC drug that has been found effective in improving melasma and stubborn spots.

Through 8 weeks of consecutive administration, it has shown proven results to improve melasma.

The main component of TRANSINO II is tranexamic acid.

Improve melasma in 3 steps!

Step 1
step1step1

Tranexamic acid inhibits plasmin signaling at an early stage.

Step 2
step2step2

L-cysteine and Vitamin C suppress the excessive formation of melanin, which is the root cause of spots.

Step 3
step3step3

Vitamin C directly reduces melanin. L-cysteine and Vitamin B6 normalize skin turnover and promote melanin excretion.

Effect of TRANSINO II according to the data

By taking it twice a day for 8 weeks (2 months), it was confirmed to be highly effective in improving "melasma."

Rate of effectiveness of TRANSINO II in improving pigmentation during each evaluation period(Skin Tone Color Scale Evaluation)

Rate of effectiveness of TRANSINO II in improving pigmentation during each evaluation period (Skin Tone Color Scale Evaluation) Rate of effectiveness of TRANSINO II in improving pigmentation during each evaluation period (Skin Tone Color Scale Evaluation)

During evaluation periods of 2 weeks, 4 weeks, 6 weeks, or 8 weeks, TRANSINO II's improvement rate (rate of effectiveness in improving pigmentation)* was 29.5%, 62.6%, 73.7%, and 85.2%, respectively. In addition, both prominent improvement and improvement cases were confirmed 2 weeks after the administration, and both increased over time until the end of 8 weeks.

*Improvement rate = (Number of prominent improvement cases + Number of improvement cases + Number of slight improvement cases) / Total

Criterial for improving pigmentation
Difference between before and after administration Difference between before and after administration
1.0 or moreProminent Improvement
0.75Improvement
0.5Slight Improvement
-0.25~0.25No Change
less than 0.25Worsen
Significant lightening of melasma was confirmed 8 weeks after administration.

TRANSINO II
Image diagnosis (V-value) result

TRANSINO II Image diagnosis (V-value) result TRANSINO II Image diagnosis (V-value) result

V-value: Lightness of the specified part* based on RSA-100 skin image analysis system.

Test: Comparison between before and after administration by Paird Sample t-test (FAS analysis)

By using RSA-100 (Robo Skin Analyzer), the lightness (V-value) of the specified part* was compared before the start of TRANSINO Ⅱ administration and at the end of administration (8 weeks after administration). As a result, the lightness has increased significantly.

*The darkest area of the melasma site marked by the physician attending at the time of first imaging.

Improvement of subjective symptoms was confirmed

Improvement of subjective symptoms after administration
(8 weeks after administration) (FAS analysis)

Improvement of subjective symptoms after administration (8 weeks after administration) (FAS analysis) Improvement of subjective symptoms after administration (8 weeks after administration) (FAS analysis)

More than 70%* of respondents answered that "Spots became less noticeable" or "Skin feels brighter now."

*Agree + Somewhat agree

Safety

The occurrence of adverse reactions was 5.2% (6/115 cases) with a total of 8 cases reported (5 gastrointestinal disorders, 1 case of abdominal pain, 2 abnormal laboratory test values). All were mild cases and no serious cases were found. <Attached Data at the Time of Application for Approval>

Product Information

Recommended administration period is 8 weeks.

TTRANSINO II PTP 60 tablets

Start with this trial size package

60 tablets for 2 weeks

TRANSINO II PTP 60 tablets

First class OTC drugs 1,800JPY (tax not included)
TRANSINO II PTP 120 tablets

Affordable 4-week package

120 tablets 1 month worth

TRANSINO II PTP 120 tablets

First class OTC drugs 3,400JPY (tax not included)
TRANSINO II PTP 240 tablets

Complete package designed to last for approximately 8 weeks.

240 tablets 2 months worth

TRANSINO II PTP 240 tablets

First class OTC drugs 6,300JPY (tax not included)
Indication
Spots (limited to melasma)
Dosage and administration
Take the following amount with water or hot water.
Adults (15 years old and over):
Take 2 tablets at a time twice daily after meals.

Do not use for children under 15 years old.

Ingredients
This tablet contains the following ingredients in 4 tablets:
  • Tranexamic Acid750mg 
  • L-cysteine240mg 
  • Ascorbic Acid (Vitamin C)300mg 
  • Pyridoxine hydrochloride (Vitamin B6)6mg 
  • Pyridoxine hydrochloride
  • (Vitamin B6)6mg 
  • Calcium Pantothenate24mg 
Additives: Calcium lactate, crystalline cellulose, croscarmelose sodium, hydroxypropyl cellulose, magnesium stearate, hypromellose, macrogol, talc, titanium oxide, iron sesquioxide, and carnauba wax.

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