Active ingredient "tranexamic acid combination"
TRANSINO II is the only OTC drug that has been found effective in improving melasma and stubborn spots.
Through 8 weeks of consecutive administration, it has shown proven results to improve melasma.
Blocks melanocyte activator
prior to melanin production
Inhibits production of
tyrosinase that forms melanin
Direct reduction of
Tranexamic acid inhibits plasmin signaling at an early stage.
L-cysteine and Vitamin C suppress the excessive formation of melanin, which is the root cause of spots.
Vitamin C directly reduces melanin. L-cysteine and Vitamin B6 normalize skin turnover and promote melanin excretion.
Rate of effectiveness of TRANSINO II in improving pigmentation during each evaluation period(Skin Tone Color Scale Evaluation)
During evaluation periods of 2 weeks, 4 weeks, 6 weeks, or 8 weeks, TRANSINO II's improvement rate (rate of effectiveness in improving pigmentation)* was 29.5%, 62.6%, 73.7%, and 85.2%, respectively. In addition, both prominent improvement and improvement cases were confirmed 2 weeks after the administration, and both increased over time until the end of 8 weeks.
*Improvement rate = (Number of prominent improvement cases + Number of improvement cases + Number of slight improvement cases) / Total
|Difference between before and after administration||Difference between before and after administration|
|1.0 or more||Prominent Improvement|
|less than 0.25||Worsen|
Image diagnosis (V-value) result
By using RSA-100 (Robo Skin Analyzer), the lightness (V-value) of the specified part* was compared before the start of TRANSINO Ⅱ administration and at the end of administration (8 weeks after administration). As a result, the lightness has increased significantly.
*The darkest area of the melasma site marked by the physician attending at the time of first imaging.
Improvement of subjective symptoms after administration
(8 weeks after administration) (FAS analysis)
More than 70%* of respondents answered that "Spots became less noticeable" or "Skin feels brighter now."
*Agree + Somewhat agree
Recommended administration period is 8 weeks.
TRANSINO II PTP 60 tabletsFirst class OTC drugs 1,800JPY (tax not included)
TRANSINO II PTP 120 tabletsFirst class OTC drugs 3,400JPY (tax not included)
TRANSINO II PTP 240 tabletsFirst class OTC drugs 6,300JPY (tax not included)
Do not use for children under 15 years old.