LOXONIN S PREMIUM fine

  • Class 1 Drug
  • Self-medication tax deductible
Fast-acting + unique formula based on the mechanism of menstrual pain
  • Antipyretic Analgesic
  • Tablet
  • 15 years of age and older
Photo: Package and product of LOXONIN S PREMIUM fine
Notice of change in packaging design for the LOXONIN Antipyretic Analgesic Series (October 2025)Open in new window

Manufacturer's suggested retail price *Tax included

12錠　768円 / 24錠　1,298円

Brand site/SNS

Ideal for:

    Those looking for an effective antipyretic and analgesic for painful menstrual pain/those looking for an antipyretic and analgesic that puts less strain on the stomach/those looking for an antipyretic and analgesic that doesn't make you drowsy
    For lower abdominal pain, lower back pain, and headaches associated with menstruation

More Information

  • "LOXONIN S PREMIUM fine" is an antipyretic and analgesic drug that is not only fast, effective, and gentle, but also takes into account the mechanism of severe menstrual pain.

    ●Contains a pain-relieving ingredient (lofecoxib sodium hydrate) that provides fast relief of severe pain.
    ●In addition, it contains two ingredients that focus on the mechanism behind painful menstrual cramps (dried peony extract, hesperidin). It relieves menstrual cramps accompanied by a tight pain in the lower abdomen.
    ●Contains magnesium aluminometasilicate, which protects the stomach by protecting the gastric mucosa.
    ●Does not contain any ingredients that cause drowsiness (sedative hypnotic ingredients).
    ●It is a small tablet that is easy to swallow.

    This product does not fall under aviation dangerous goods as defined by the Civil Aviation Law.

  • Things to avoid

    (If these guidelines are not followed, your current symptoms may worsen and side effects are more likely to occur.)

    1. Please do not take this medicine for the following people:
    (1) Persons who have had allergic symptoms due to this drug or its ingredients
    (2) People who have had asthma while taking this drug or other antipyretic analgesics or cold medicines
    (3) Children under 15 years old
    (4) Persons receiving the following treatment at a medical institution:
    Stomach/duodenal ulcer, liver disease, kidney disease, heart disease
    (5) People whose doctor has pointed out a blood abnormality (blood disease) such as a low number of red blood cells (anemia), a low number of platelets (difficult to stop blood, easy bleeding), or a low number of white blood cells.
    (6) Pregnant women within 12 weeks of due date
    2. Do not take any of the following medicines while taking this drug.
    Other antipyretic analgesics, cold medicines, and sedatives
    3. Do not drink alcohol before or after taking this medicine.
    Four. Please do not take it continuously for a long period of time. (If symptoms such as pain recur even after taking it for 3 to 5 days, please stop taking it and consult a doctor.)


    Things to consult


    1. The following people should consult a doctor, dentist, or pharmacist before taking this medicine.
    (1) People receiving medical treatment from a doctor or dentist
    (2) Pregnant women or those suspected to be pregnant
    (3) People who are breastfeeding
    (4) Elderly people
    (5) People who have experienced allergic symptoms due to medicine, etc.
    (6) People who have been diagnosed with the following:
    Bronchial asthma, ulcerative colitis, Crohn's disease, systemic lupus erythematosus, mixed connective tissue disease
    (7) People who have had the following diseases: stomach or duodenal ulcer, liver disease, kidney disease, blood disease

    2. If the following symptoms are observed after taking this medicine, these may be side effects, so discontinue use immediately and consult a doctor, dentist, or pharmacist with this leaflet.
    (1) If symptoms such as excessive drop in body temperature, weakness, or cold extremities (cold hands and feet) appear after taking an antipyretic analgesic such as this drug.
    (2) If you experience peptic ulcers or swelling after taking the medicine.
    In rare cases, serious symptoms such as gastrointestinal bleeding (vomiting blood, nausea, vomiting, abdominal pain, black tarry stools, bloody stools, etc.) may occur, gastrointestinal perforation (a hole in the gastrointestinal tract, causing nausea, vomiting, severe abdominal pain, etc.), and small or large intestinal stenosis or obstruction (causing nausea, vomiting, abdominal pain, abdominal distension, etc.). If this occurs, consult a doctor immediately.
    (3) If the following symptoms occur after taking the medicine:
    Affected area: Symptoms
    Skin: rash, redness, itching
    Digestive system: abdominal pain, stomach discomfort, loss of appetite, nausea, vomiting, abdominal distension, heartburn, stomatitis, indigestion
    Circulatory system: Increased blood pressure, palpitations
    Psychological nervous system: drowsiness, numbness, dizziness, headache
    Other: Chest pain, fatigue, facial flushing, fever, anemia, hematuria

    In rare cases, the following serious symptoms may occur. If this occurs, consult a doctor immediately.
    Symptom name: Symptoms
    Shock (anaphylaxis): Immediately after taking the drug, symptoms may include itchy skin, hives, hoarseness, sneezing, itchy throat, shortness of breath, palpitations, and confusion.
    Blood disorders: Symptoms include sore throat, fever, general fatigue, paleness of the face or the insides of the eyelids, increased bleeding (bleeding gums, nosebleeds, etc.), and blue bruises (which do not go away when pressed).
    Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, acute generalized exanthematous pustulosis: high fever, bloodshot eyes, eye discharge, sores on the lips, sore throat, widespread rash/redness on the skin, blisters appearing on red areas of the skin, small bumps (pustules) appearing on the red skin, generalized fatigue, loss of appetite, etc. may persist or suddenly worsen.
    Kidney damage: Symptoms include fever, rash, decreased urine output, generalized swelling, general fatigue, joint pain, and diarrhea.
    Congestive heart failure: Symptoms include general fatigue, palpitations, shortness of breath, chest discomfort, chest pain, dizziness, and fainting.
    Myocardial infarction...constraining chest pain, shortness of breath, cold sweat.
    Cerebrovascular disorder: Symptoms such as sudden decrease or loss of consciousness, difficulty moving one side of the limbs, headache, vomiting, dizziness, difficulty speaking, and difficulty speaking may occur.
    Interstitial pneumonia: When climbing stairs or exerting yourself slightly, you may experience shortness of breath, difficulty breathing, dry cough, fever, etc. These symptoms may appear suddenly or persist.
    Liver dysfunction: Symptoms include fever, itching, rash, jaundice (yellowing of the skin and whites of the eyes), brown urine, general fatigue, and loss of appetite.
    Rhabdomyolysis: Symptoms include muscle pain in the arms, legs, shoulders, waist, etc., numbness, weakness, stiffness in the arms and legs, general fatigue, and reddish-brown urine.
    Aseptic meningitis: Symptoms include a severe headache accompanied by stiffness in the neck, fever, nausea, vomiting, etc. (These symptoms have been reported frequently, particularly in people receiving treatment for systemic lupus erythematosus or mixed connective tissue disease.)
    Asthma: Symptoms include wheezing or difficulty breathing when breathing.

    3. The following symptoms may occur after taking this medicine. If these symptoms persist or worsen, discontinue use and consult a doctor or pharmacist with this leaflet.
    Dry mouth, constipation, diarrhea

    4. If symptoms do not improve after taking the medicine 1 or 2 times (this may be due to the possibility of other diseases), stop taking the medicine and consult a doctor, dentist or pharmacist with this leaflet.

  • 〇 Pain relief for menstrual pain, headache, toothache, pain after tooth extraction, sore throat, low back pain, joint pain, neuralgia, muscle pain, stiff shoulder pain, earache, bruise pain, fracture pain, sprain pain, trauma pain
    〇 Antipyretic at the time of chills and fever

  • Please take the following amount with water or lukewarm water.
    Adults (15 years of age and older)
    Dosage2 tablets
    Number of doses per dayUp to 2 times.
    When symptoms appear, avoid taking this medicine on an empty stomach as much as possible.
    However, if symptoms appear again, you can take a third dose.
    Please allow at least 4 hours between doses.
    Under 15
    Dosage-
    Number of doses per dayPlease do not take.
    <Caution regarding dosage and administration>
    (1) Please strictly follow the usage and dosage instructions.
    (2) How to take out the tablets
    As shown in the right figure, press firmly with your fingertips on the raised part of the PTP sheet containing the tablet, break the aluminum foil on the back, take out the tablet and take it. (If swallowed by mistake, it may cause an unexpected accident such as the tablet piercing the esophageal mucosa.)


    ※This medicine is prescribed by a pharmacist. "Precautions for Use" Please read the instructions carefully before using. If you have allergies, please be sure to consult us.

  • This product is a light red film-coated tablet containing the following ingredients in 2 tablets.
    Loxoprofen sodium hydrate
    Amount68.1mg
    (60mg as anhydrous)
    FunctionSuppresses prostaglandin, the source of inflammation and pain.
    peony dry extract
    Amount36mg
    (252mg as crude drug)
    FunctionSuppresses excessive muscle contraction and helps reduce pain.
    Hesperidin
    Amount30mg
    FunctionHelps to reduce pain.
    Magnesium aluminometasilicate
    Amount100mg
    FunctionProtects the gastric mucosa.
    [Additives]
    D-mannitol, cellulose, croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate, hypromellose, titanium dioxide, macrogol, ferric oxide, carnauba wax

  • (1) Store in a cool, dry place away from direct sunlight.
    (2) Please keep out of reach of children.
    (3) Please do not replace it with another container. (This may cause misuse or change in quality)
    (4) Do not use products whose expiration date has passed. Also, once the aluminum bag is opened, please use it within 12 months.
    (5) Please write the date you opened the aluminum bag in the "Date opened" field on the box.

  • LOXONIN S PREMIUM fine

    Packaging unit 12 tablets24 tablets
    Manufacturer's suggested retail price (10% tax included) 698円(768円)1,180円(1,298円)
    JAN Code 4987 107 6346964987 107 634702
    Individual packaging size Width x Depth x Height (mm) 105x18x50105x25x50
    Packaging unit
    12 tablets / 24 tablets
    Manufacturer's suggested retail price (10% tax included)
    12 tablets 698円(768円)
    24 tablets 1,180円(1,298円)
    JAN Code
    12 tablets 4987 107 634696
    24 tablets 4987 107 634702
    Individual package size width x depth x height (mm)
    12 tablets 105x18x50
    24 tablets 105x25x50

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